An estimated 300 million people are infected with the hepatitis B virus (HBV) in the Asia-Pacific region. Healthcare professionals need to be able to identify which individuals are at risk for HBV infection and to follow current recommendations for screening and vaccination. Over the course of chronic hepatitis B, changing patterns in the levels of liver function enzymes and HBV DNA, as well as in antigen and antibody status, present a challenge to clinicians in the accurate interpretation of diagnostic test results. Such interpretation is essential for determining a patient’s stage of disease and the indications for treatment. Published guidelines and treatment algorithms can assist healthcare professionals in appropriately monitoring patients and selecting therapy. The suppression of viral load to the lowest possible level— rather than cure— is the goal of antiviral therapy. Understanding the efficacy, safety, and resistance profiles of currently approved therapies for the management of chronic hepatitis B is key to their effective use and to optimal patient outcomes.
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